| |
|
acetil-CoA
^
|
|
----------------------------------------> |
| |
| CICLO DELL'ACIDO CITRICO |
| citrate synthase |
| |
| |-> CoASH, H2O
| |
| v
| cytrate
| ^
| |
| aconitate hydratase |
| (aconitase) |-> H20
| |
| v
| cis-aconitate
| ^
| |
| aconitate hydratase |
| (aconitase) |-> H20
| |
| v
| threo-Ds-isocitrate <---------------------------
| ^ |
| | |
| |<- NADP+ |<- NAD+
| isocitrate dehydrogenase (NADP) | isocitrate dehydrogenase (NAD+) |
| | |
| |-> NADPH+H+ |-> CO2, NADH+H+
| | |
| v |
| oxalosuccinate |
| ^ |
| | |
| isocitrate dehydrogenase (NADP) | |
| | |
| v |
| 2oxo-glutarate <-------------------------------
| |
| |<--------------------------------------
| | |
| 2oxoglutarate decarboxylase | 2oxoglutarate dehydrogenase system |
| | |
| |---------------------------------------
| |
| |<--- --> FAD.E ------------------------ <-- NAD+
| | ^ |
| dihydrolipoamidesuccinyltransferase | | dihydrolipoadide dehydrogenase |
| | | v
| |---> <-- FADH2.E ---------------------- --> NADH+H+
| |
| |-> CO2
| v
| succinyl-CoA
| ^
| |
| succinylCoA ligase |
| |
| v
| succinate
| ^
| |<- FAD.E <-- --> ubiquinol
| | ^
| succinate dehydrogenase | |
| | |
| |-> FADH2.E -- <-- ubiquinone
| v
| fumarate
| ^
| |
| fumarate hydratase |
| |
| v
| malate
| ^
| |
| |<- NAD+
| malate dehydrogenase |
| |-> NADH+H+
| |
| v
| oxaloacetate
| ^
| |
------------------------------------------
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